Products

anti- ERCC2 antibody

FNab02833 Catalogue No.
Synonyms
XPD, XPDC
Host
Rabbit
Reactivity
Human
Isotype
IgG
Tested Application
ELISA, WB, IHC, IP
Product Information
Product Name
anti- ERCC2 antibody
Catalogue No.
FNab02833
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair(NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase(CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
Immunogen Information
Immunogen
excision repair cross-complementing rodent repair deficiency, complementation group 2
Synonyms
XPD, XPDC
Observed MW
80 kDa
Application
Tested Application
ELISA, WB, IHC, IP
Recommended dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Uniprot information
UniProt ID
P18074
Images
Immunohistochemistry of paraffin-embedded human lymphoma using FNab02833(ERCC2 antibody) at dilution of 1:100
IP Result of anti-ERCC2 (IP:FNab02833, 5ug; Detection:FNab02833 1:500) with K-562 cells lysate 8000ug.
HeLa cells were subjected to SDS PAGE followed by western blot with FNab02833(ERCC2 antibody) at dilution of 1:500