Products
ERCC2 antibody
- Product Name
- ERCC2 antibody
- Catalogue No.
- FNab02833
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- excision repair cross-complementing rodent repair deficiency, complementation group 2
- Alternative Names
- XPD antibody, XPDC antibody
- UniProt ID
- P18074
- Observed MW
- 80 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab02833(ERCC2 antibody) at dilution of 1:500
IP Result of anti-ERCC2 (IP:FNab02833, 5ug; Detection:FNab02833 1:500) with K-562 cells lysate 8000ug.
Immunohistochemistry of paraffin-embedded human lymphoma using FNab02833(ERCC2 antibody) at dilution of 1:100
- Background
- ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair(NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase(CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
