Products
EPHB4 antibody
- Product Name
- EPHB4 antibody
- Catalogue No.
- FNab02807
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- EPH receptor B4
- Alternative Names
- EPH receptor B4 antibody, EPHB4 antibody, Ephrin type B receptor 4 antibody, HTK antibody, MYK1 antibody, TYRO11 antibody, Tyrosine protein kinase TYRO11 antibody
- UniProt ID
- P54760
- Observed MW
- 110kd
Application
- Tested Applications
- ELISA, IHC, FC, WB
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab02807(EPHB4 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human pancreas tissue using FNab02807(EPHB4 antibody) at dilution of 1:50
- Background
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
