Products
DTX1 antibody
- Product Name
- DTX1 antibody
- Catalogue No.
- FNab02553
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- deltex homolog 1(Drosophila)
- UniProt ID
- Q86Y01
- Observed MW
- 67-72,58-63 kDa
Application
- Tested Applications
- ELISA, IF, IHC
- Recommended dilution
- IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
Immunohistochemistry of paraffin-embedded human colon cancer using FNab02553(DTX1 antibody) at dilution of 1:100
- Background
- Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity(By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB(Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
