Products
DOCK7 antibody
- Product Name
- DOCK7 antibody
- Catalogue No.
- FNab02497
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- dedicator of cytokinesis 7
- Alternative Names
- dedicator of cytokinesis 7 antibody, DOCK7 antibody, KIAA1771 antibody, ZIR2 antibody
- UniProt ID
- Q96N67
- Observed MW
- 240 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:200-1:1000; IP: 1:500-1:1000
Validated Images
mosue brain tissue were subjected to SDS PAGE followed by western blot with FNab02497(DOCK7 antibody) at dilution of 1:400
IP Result of anti-DOCK7 (IP: FNab02497, 3ug; Detection: FNab02497 1:500) with mouse brain tissue lysate 8000ug.
- Background
- Functions as a guanine nucleotide exchange factor(GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization(PubMed:16982419). Has a role in pigmentation(By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells(RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3(By similarity).Multiple isoforms of DOCK 7 exist due to alternative splicing events. This DOCK 7 antibody can recognize all the isoforms.
