mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab02443(DNAJB11 Antibody) at dilution of 1:3000
IP Result of anti-DNAJB11 (IP:FNab02443, 4ug; Detection:FNab02443 1:500) with mouse heart tissue lysate 3200ug.
Immunohistochemistry of paraffin-embedded human ovary tumor using FNab02443(DNAJB11 antibody) at dilution of 1:100
Background
Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.