Products
DHX36 antibody
- Product Name
- DHX36 antibody
- Catalogue No.
- FNab02380
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- DEAH(Asp-Glu-Ala-His) box polypeptide 36
- Alternative Names
- DDX36 antibody, KIAA1488 antibody, MLEL1 antibody, RHAU antibody
- UniProt ID
- Q9H2U1
- Observed MW
- 120 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
human brain tissue were subjected to SDS PAGE followed by western blot with FNab02380(DHX36 antibody) at dilution of 1:800
IP Result of anti-DHX36 (IP:FNab02380, 5ug; Detection:FNab02380 1:500) with PC-3 cells lysate 1880ug.
Immunohistochemistry of paraffin-embedded human prostate using FNab02380(DHX36 antibody) at dilution of 1:50
- Background
- Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component(TERC) 5'-end(nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.
