Products
DBNL antibody
- Product Name
- DBNL antibody
- Catalogue No.
- FNab02257
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- drebrin-like
- Alternative Names
- CMAP antibody, SH3P7 antibody
- UniProt ID
- Q9UJU6
- Observed MW
- 55 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab02257(DBNL antibody) at dilution of 1:1000
IP Result of anti-DBNL (IP:FNab02257, 4ug; Detection:FNab02257 1:1000) with mouse brain tissue lysate 2640ug.
Immunohistochemistry of paraffin-embedded human breast cancer using FNab02257(DBNL antibody) at dilution of 1:100
- Background
- Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes(By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
