Products

CXCR3B-specific antibody

Synonyms:CD183 antibody, CKR L2 antibody, CMKAR3 antibody, CXC R3 antibody, CXCR 3 antibody, CXCR3 antibody, CXCR3A antibody, CXCR3B antibody, G protein coupled receptor 9 antibody, GPR9 antibody, IP 10 receptor antibody, IP10 R antibody, Mig R antibody, MigR antibody
Catalogue No.:FNab02101Reativity:Human
Host:MouseTested Application:ELISA, WB
Clonality:monoclonalIsotype:IgG1
  • SPECIFICATIONS
Product Name
CXCR3B-specific antibody
Catalogue No.
FNab02101
Size
100μg
Form
liquid
Purification
Protein A+G purification
Purity
≥95% as determined by SDS-PAGE
Clonality
monoclonal
Isotype
IgG1
Clone ID
6F7
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
chemokine(C-X-C motif) receptor 3
Alternative Names
CD183 antibody, CKR L2 antibody, CMKAR3 antibody, CXC R3 antibody, CXCR 3 antibody, CXCR3 antibody, CXCR3A antibody, CXCR3B antibody, G protein coupled receptor 9 antibody, GPR9 antibody, IP 10 receptor antibody, IP10 R antibody, Mig R antibody, MigR antibody
UniProt ID
P49682
Observed MW
40 kDa +43 kDa
Application
Tested Applications
ELISA, WB
Recommended dilution
WB: 1:500-1:5000
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab02101(CXCR3B antibody) at dilution of 1:2000
Background
CXCR3(C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells(PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. Binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury(PMID: 17250586). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4(PMID:12782716). This monoclonal antibody is specific to CXCR3B.