Products
COPS8 antibody
- Product Name
- COPS8 antibody
- Catalogue No.
- FNab01874
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- COP9 constitutive photomorphogenic homolog subunit 8(Arabidopsis)
- Alternative Names
- COP9 antibody, COP9 homolog antibody, COPS8 antibody, CSN8 antibody, hCOP9 antibody, SGN8 antibody, Signalosome subunit 8 antibody
- UniProt ID
- Q99627
- Observed MW
- 23 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab01874(COPS8 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab01874(COPS8 Antibody) at dilution of 1:50
- Background
- Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
