Products
COPS7A antibody
- Product Name
- COPS7A antibody
- Catalogue No.
- FNab01873
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- COP9 constitutive photomorphogenic homolog subunit 7A(Arabidopsis)
- Alternative Names
- CSN7A antibody, DERP10 antibody
- UniProt ID
- Q9UBW8
- Observed MW
- 30 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
human heart tissue were subjected to SDS PAGE followed by western blot with FNab01873(COPS7A antibody) at dilution of 1:300
IP Result of anti-COPS7A (IP:FNab01873, 4ug; Detection:FNab01873 1:300) with mouse heart tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human kidney using FNab01873(COPS7A antibody) at dilution of 1:50
- Background
- Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
