Products
COPS4 antibody
- Product Name
- COPS4 antibody
- Catalogue No.
- FNab01872
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- COP9 constitutive photomorphogenic homolog subunit 4(Arabidopsis)
- Alternative Names
- CSN4 antibody
- UniProt ID
- Q9BT78
- Observed MW
- 40; 46 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
A2780 cells were subjected to SDS PAGE followed by western blot with FNab01872(COPS4 antibody) at dilution of 1:500
IP Result of anti-COPS4 (IP:FNab01872, 4ug; Detection:FNab01872 1:300) with PC-3 cells lysate 1800ug.
Immunohistochemistry of paraffin-embedded human pancreas tissue slide using FNab01872(COPS4 Antibody) at dilution of 1:50
- Background
- Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
