Products
COMMD5 antibody
- Product Name
- COMMD5 antibody
- Catalogue No.
- FNab01851
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- COMM domain containing 5
- UniProt ID
- Q9GZQ3
- Observed MW
- 25-28 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:2000
Validated Images
mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab01851(COMMD5 antibody) at dilution of 1:1000
IP Result of anti-COMMD5 (IP:FNab01851, 4ug; Detection:FNab01851 1:500) with mouse heart tissue lysate 3200ug.
- Background
- May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes(PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis(By similarity). Down-regulates activation of NF-kappa-B(PubMed:15799966).
