Products
Collagen Type IV antibody
- Product Name
- Collagen Type IV antibody
- Catalogue No.
- FNab01844
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- collagen, type IV, alpha 2
- Alternative Names
- COL4A2 antibody, Collagen alpha 2(IV) chain antibody, Collagen Type IV antibody, collagen antibody, type IV antibody, alpha 2 antibody, DKFZp686I14213 antibody, FLJ22259 antibody
- UniProt ID
- P08572
- Observed MW
- 200 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200
Validated Images
NIH/3T3 were subjected to SDS PAGE followed by western blot with FNab01844(Collagen Type IV Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab01844(Collagen Type IV antibody) at dilution of 1:50
- Background
- Type IV collagen is the major structural component of glomerular basement membranes(GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and-9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
