Products
CNOT7 antibody
- Product Name
- CNOT7 antibody
- Catalogue No.
- FNab01811
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- CCR4-NOT transcription complex, subunit 7
- Alternative Names
- CAF1 antibody
- UniProt ID
- Q9UIV1
- Observed MW
- 33-35 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:2000
Validated Images
mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab01811(CNOT7 antibody) at dilution of 1:500
IP Result of anti-CNOT7 (IP:FNab01811, 4ug; Detection:FNab01811 1:300) with mouse testis tissue lysate 4800ug.
- Background
- Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
