Products
CNOT3 antibody
- Product Name
- CNOT3 antibody
- Catalogue No.
- FNab01808
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- CCR4-NOT transcription complex, subunit 3
- Alternative Names
- KIAA0691 antibody, LENG2 antibody, NOT3 antibody
- UniProt ID
- O75175
- Observed MW
- 120 kDa
Application
- Tested Applications
- ELISA, WB, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Validated Images
Raji cells were subjected to SDS PAGE followed by western blot with FNab01808(CNOT3 antibody) at dilution of 1:500
IP Result of anti-CNOT3 (IP:FNab01808, 4ug; Detection:FNab01808 1:1000) with HeLa cells lysate 3200ug.
- Background
- Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem(ES) cell identity.
