anti- Chk1 antibody
FNab01653
Catalogue No.
- Synonyms:
- CHEK1, Chk1
- Host:
- Mouse
- Reactivity:
- Human, Mouse, Rat
- Isotype:
- IgG2a
- Tested Application:
- ELISA, WB, IHC
Product Information
- Product Name
- anti- Chk1 antibody
- Catalogue No.
- FNab01653
- Size
- 100µg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Host
- Mouse
- Clonality
- monoclonal
- Isotype
- IgG2a
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
- HEK1 (Checkpoint kinase-1) is also named as CHK1 and belongs to the protein kinase superfamily. It is implicated in a circuit in which it activates checkpoints, DNA repair and proliferating cell nuclear antigen and FANCD2 monoubiquitinylation (PMID:21389083) . CHEK1 protects vertebrate cells against spontaneous chromosome missegregation and is required to sustain anaphase delay when spindle function is disrupted by taxol (PMID:17276342) . It has 3 isoforms produced by alternative splicing with the molecular mass of 54 kDa, 44 kDa and 50 kDa.
Immunogen Information
- Immunogen
- CHK1 checkpoint homolog
- Synonyms
- CHEK1, Chk1
- Observed MW
- 50 kDa
Application
- Tested Application
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Uniprot information
- UniProt ID
- O14757
Images
- Image 1
-
Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab01653 (CHK1 Antibody) at dilution of 1:50
- Image 4
-
HeLa cells were subjected to SDS PAGE followed by western blot with FNab01653 (CHK1 Antibody) at dilution of 1:1000