Products
CEP63 antibody
- Product Name
- CEP63 antibody
- Catalogue No.
- FNab01606
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- centrosomal protein 63kDa
- UniProt ID
- Q96MT8
- Observed MW
- 57-75kd
Application
- Tested Applications
- ELISA, WB, IF, IP, IHC
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
human placenta tissue were subjected to SDS PAGE followed by western blot with FNab01606(CEP63 antibody) at dilution of 1:800
IP Result of anti-CEP63 (IP:FNab01606, 3ug; Detection:FNab01606 1:500) with HEK-293 cells lysate 1700ug.
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab01606(CEP63 Antibody) at dilution of 1:50
- Background
- Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned(PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes(PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks(DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression(PubMed:21406398).
