Products
CEP152 antibody
- Product Name
- CEP152 antibody
- Catalogue No.
- FNab01597
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- centrosomal protein 152kDa
- Alternative Names
- KIAA0912 antibody
- UniProt ID
- O94986
- Observed MW
- 110 kDa
Application
- Tested Applications
- ELISA, IP, WB
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab01597( CEP152 Antibody) at dilution of 1:300
IP Result of anti-CEP152 (IP:FNab01597, 3ug; Detection:FNab01597 1:500) with mouse brain tissue lysate 9500ug.
- Background
- Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication(PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation(PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure(PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles(By similarity). Overexpression of CEP152 can drive amplification of centrioles(PubMed:20852615).
