K-562 cells were subjected to SDS PAGE followed by western blot with FNab01520(CDC23 Antibody) at dilution of 1:500
Background
Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.