Products

anti- CD320 antibody

FNab01466 Catalogue No.
Synonyms
8D6, 8D6 antigen, 8D6A, CD320, CD320 antigen, CD320 molecule, FDC signaling molecule 8D6, FDC SM 8D6, TCblR, Transcobalamin receptor
Host
Rabbit
Reactivity
Human, Mouse
Isotype
IgG
Tested Application
ELISA, WB, IHC
Product Information
Product Name
anti- CD320 antibody
Catalogue No.
FNab01466
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
CD320, also known as 8D6, 8D6A or TCblR, is a single-pass type I membrane protein containing 2 LDL-receptor class A domains. Expressed abundantly on follicular dendritic cells (FDCs), CD320 has been shown to enhance proliferation of germinal center (GC) B cells. It is the receptor for cellular uptake of transcobalamin-bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC). CD320 has a calculated molecular mass of 29 kDa. This antibody detects bands at 50-55 kDa and 60-70 kDa, probably caused by extensive complex glycosylation.
Immunogen Information
Immunogen
CD320 molecule
Synonyms
8D6, 8D6 antigen, 8D6A, CD320, CD320 antigen, CD320 molecule, FDC signaling molecule 8D6, FDC SM 8D6, TCblR, Transcobalamin receptor
Observed MW
50-55 kDa, 60-70 kDa
Application
Tested Application
ELISA, WB, IHC
Recommended dilution
WB: 1:500-1:1000; IHC: 1:20-1:200
Uniprot information
UniProt ID
Q9NPF0
Images
Immunohistochemistry of paraffin-embedded human tonsillitis using FNab01466(CD320 antibody) at dilution of 1:50
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab01466(CD320 antibody) at dilution of 1:500