Products
CD320 antibody
- Product Name
- CD320 antibody
- Catalogue No.
- FNab01466
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- CD320 molecule
- Alternative Names
- 8D6 antibody, 8D6 antigen antibody, 8D6A antibody, CD320 antibody, CD320 antigen antibody, CD320 molecule antibody, FDC signaling molecule 8D6 antibody, FDC SM 8D6 antibody, TCblR antibody, Transcobalamin receptor antibody
- UniProt ID
- Q9NPF0
- Observed MW
- 50-55 kDa, 60-70 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:20-1:200
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab01466(CD320 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human tonsillitis using FNab01466(CD320 antibody) at dilution of 1:50
- Background
- CD320, also known as 8D6, 8D6A or TCblR, is a single-pass type I membrane protein containing 2 LDL-receptor class A domains. Expressed abundantly on follicular dendritic cells (FDCs), CD320 has been shown to enhance proliferation of germinal center (GC) B cells. It is the receptor for cellular uptake of transcobalamin-bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC). CD320 has a calculated molecular mass of 29 kDa. This antibody detects bands at 50-55 kDa and 60-70 kDa, probably caused by extensive complex glycosylation.
