K-562 cells were subjected to SDS PAGE followed by western blot with FNab01386(CCNY antibody) at dilution of 1:1000
IP Result of anti-CCNY (IP:FNab01386, 3ug; Detection:FNab01386 1:600) with K-562 cells lysate 2400ug.
Background
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.