Products
CBS antibody
- Product Name
- CBS antibody
- Catalogue No.
- FNab01327
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- cystathionine-beta-synthase
- Alternative Names
- Beta thionase antibody, CBS antibody, cystathionine beta synthase antibody, HIP4 antibody, Serine sulfhydrase antibody
- UniProt ID
- P35520
- Observed MW
- 61 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:20-1:200
Validated Images
mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab01327(CBS antibody) at dilution of 1:500
IP Result of anti-CBS (IP:FNab01327, 3ug; Detection:FNab01327 1:500) with mouse kidney tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using FNab01327(CBS Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Immunofluorescent analysis of U2OS cells, using FNab01327(CBS Antibody) at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Background
- Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine(PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons(By similarity).
