human heart tissue were subjected to SDS PAGE followed by western blot with FNab01299(CASQ2 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab01299(CASQ2 Antibody) at dilution of 1:200
Background
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.