Products
Caspase 1 antibody
- Product Name
- Caspase 1 antibody
- Catalogue No.
- FNab01284
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- caspase 1, apoptosis-related cysteine peptidase(interleukin 1, beta, convertase)
- Alternative Names
- CASP 1 antibody, CASP1 antibody, Caspase 1 antibody, Caspase 1/p20/p10 antibody, Caspase1 antibody, ICE antibody, IL 1 beta converting enzyme antibody, IL 1BC antibody, IL1BC antibody, IL1BCE antibody, Interleukin 1 beta convertase antibody, p10 antibody, p20 antibody, P45 antibody
- UniProt ID
- P29466
- Observed MW
- 45-47 kDa, 30 kDa, 35 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000,IHC: 1:20-1:200
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab01284(CASP1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human spleen tissue slide using FNab01284(Caspase 1 Antibody) at dilution of 1:100
- Background
- CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta(IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing.
