Products
BMI1 antibody
- Product Name
- BMI1 antibody
- Catalogue No.
- FNab00914
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 8D5
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- BMI1 polycomb ring finger oncogene
- Alternative Names
- BMI1 antibody, PCGF4 antibody, Polycomb complex protein BMI 1 antibody, RING finger protein 51 antibody, RNF51 antibody
- UniProt ID
- P35226
- Observed MW
- 37 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
U-937 cells were subjected to SDS PAGE followed by western blot with FNab00914(BMI1 Antibody) at dilution of 1:1000
IP Result of anti-BMI1 (IP:FNab00914, 3ug; Detection:FNab00914 1:1000) with HEK-293 cells lysate 1800ug.
Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using FNab00914(BMI1 Antibody) at dilution of 1:50
- Background
- Component of a Polycomb group(PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
