U-937 cells were subjected to SDS PAGE followed by western blot with FNab00914(BMI1 Antibody) at dilution of 1:1000
IP Result of anti-BMI1 (IP:FNab00914, 3ug; Detection:FNab00914 1:1000) with HEK-293 cells lysate 1800ug.
Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using FNab00914(BMI1 Antibody) at dilution of 1:50
Background
Component of a Polycomb group(PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.