Products
BHLHE41 antibody
- Product Name
- BHLHE41 antibody
- Catalogue No.
- FNab00889
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- basic helix-loop-helix family, member e41
- Alternative Names
- BHLHB3 antibody, DEC2 antibody, SHARP1 antibody
- UniProt ID
- Q9C0J9
- Observed MW
- 51 kDa, 75 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:1000-1:2000
Validated Images
mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab00889(BHLHE41 antibody) at dilution of 1:1000
- Background
- Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.
