Products
ATX3,ATXN3 antibody
- Product Name
- ATX3,ATXN3 antibody
- Catalogue No.
- FNab00739
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ataxin 3
- Alternative Names
- AT3 antibody, ataxin 3 antibody, ATX3 antibody, ATXN3 antibody, JOS antibody, MJD antibody, MJD1 antibody, SCA3 antibody
- UniProt ID
- P54252
- Observed MW
- 38 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:20-1:200
Validated Images
mouse pancreas tissue were subjected to SDS PAGE followed by western blot with FNab00739(ATX3,ATXN3 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab00739(ATX3,ATXN3 antibody) at dilution of 1:100
- Background
- ATXN3, which has deubiquitinase activity and act as a component of the ubiquitin proteasome system, plays a role in transcriptional regulation and neuroprotection. ATXN3 interacts with RAD23, HHR23A and HHR23B, involves in the pathology of MJD. ATXN3 is a mixed-linkage, chain-editing enzyme and that the UIM region of ATXN3 regulates its substrate specificity. Contains an N-terminal deubiquitinating domain, called the Josephin domain, followed by 2 ubiquitin-interacting motifs (UIMs) and a polyQ tract near the C terminus. ATXN3 can be phosphorylated in a protein casein kinase-2-dependent manner, thus the MW would be larger than the predicted one.
