Products
ARHGEF4 antibody
- Product Name
- ARHGEF4 antibody
- Catalogue No.
- FNab00562
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Rho guanine nucleotide exchange factor(GEF) 4
- Alternative Names
- KIAA1112 antibody
- UniProt ID
- Q9NR80
- Observed MW
- 72 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00562(ARHGEF4 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human brain tissue slide using FNab00562(ARHGEF4 Antibody) at dilution of 1:50
- Background
- Acts as guanine nucleotide exchange factor(GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
