human blood tissue were subjected to SDS PAGE followed by western blot with FNab00518(APRT antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse lung using FNab00518(APRT antibody) at dilution of 1:50
Background
Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2, 8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene.