human brain tissue were subjected to SDS PAGE followed by western blot with FNab00515(APPL1 antibody) at dilution of 1:500
IP Result of anti-APPL1 (IP:FNab00515, 4ug; Detection:FNab00515 1:500) with mouse brain tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human ovary tumor using FNab00515(APPL1 antibody) at dilution of 1:50
Background
Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway.