Products

anti- AMBRA1 antibody

FNab00356 Catalogue No.
Synonyms
AMBRA1, autophagy/beclin 1 regulator 1, FLJ20294, KIAA1736, WDR94
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Tested Application
ELISA, IHC, WB
Product Information
Product Name
anti- AMBRA1 antibody
Catalogue No.
FNab00356
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. AMBRA1 (Activating molecule in BECN1-regulated autophagy protein 1) , also known as WDR94 or KIAA1736, is a 1, 298 amino acid protein that contains three WD repeats. Localized to cytoplasmic vesicles, AMBRA1 functions to control protein turnover, cell proliferation and cell survival during neuronal development, thereby playing an important role in autophagy and the development of the nervous system. Multiple isoforms of AMBRA1 exist due to alternative spicing events.
Immunogen Information
Immunogen
autophagy/beclin-1 regulator 1
Synonyms
AMBRA1, autophagy/beclin 1 regulator 1, FLJ20294, KIAA1736, WDR94
Observed MW
140 kDa
Application
Tested Application
ELISA, IHC, WB
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Uniprot information
UniProt ID
Q9C0C7
Images
Immunohistochemistry of paraffin-embedded rat kidney using FNab00356 (AMBRA1 antibody) at dilution of 1:50
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00356 (AMBRA1 antibody) at dilution of 1:1000