Products
ALKBH7 antibody
- Product Name
- ALKBH7 antibody
- Catalogue No.
- FNab00315
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- alkB, alkylation repair homolog 7(E. coli)
- Alternative Names
- ABH7 antibody, ALKBH7 antibody, SPATA11 antibody, UNQ6002 antibody
- UniProt ID
- Q9BT30
- Observed MW
- 25 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200
Validated Images
human testis tissue were subjected to SDS PAGE followed by western blot with FNab00315(ALKBH7 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab00315(ALKBH7 Antibody) at dilution of 1:50
- Background
- May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110(in vitro), but this activity may be due to the absence of the true substrate(PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death(PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage(PubMed:23666923). Does not display DNA demethylase activity(PubMed:23666923). Involved in fatty acid metabolism(By similarity).
