Products
ALK,CD246 antibody
- Product Name
- ALK,CD246 antibody
- Catalogue No.
- FNab00310
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 2B10
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- anaplastic lymphoma receptor tyrosine kinase
- Alternative Names
- ALK antibody, ALK tyrosine kinase receptor antibody, ALK antibody, CD246 antibody, Anaplastic lymphoma kinase antibody, CD246 antibody, TFG/ALK antibody
- UniProt ID
- Q9UM73
- Observed MW
- 176 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
Recombinant protein were subjected to SDS PAGE followed by western blot with FNab00310(ALK,CD246 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lymphoma slide using FNab00310(ALK,CD246 Antibody) at dilution of 1:50
- Background
- ALK, also named as CD246, is a receptor tyrosine kinase(RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM(Nucleophosmin)-ALK oncogenic fusion protein, resulting from the(2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma(ALCL). The EML4(echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer(NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC(PMID: 17625570).
