Products
AKTIP antibody
- Product Name
- AKTIP antibody
- Catalogue No.
- FNab00274
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- AKT interacting protein
- Alternative Names
- AKT interacting protein antibody, AKTIP antibody, FT1 antibody, FTS antibody, Fused toes protein homolog antibody
- UniProt ID
- Q9H8T0
- Observed MW
- 36 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with FNab00274( AKTIP Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat brain using FNab00274(AKTIP antibody) at dilution of 1:100
- Background
- The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
