Products
AKR1C4 antibody
- Product Name
- AKR1C4 antibody
- Catalogue No.
- FNab00263
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
- Alternative Names
- AKR1C4 antibody, HAKRA antibody, CHDR antibody, 3 alpha HSD1 antibody, Chlordecone reductase antibody
- UniProt ID
- P17516
- Observed MW
- 37 kDa
Application
- Tested Applications
- ELISA, WB, IF
- Recommended dilution
- WB: 1:1000-1:10000; IF: 1:10-1:100
Validated Images
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab00263(AKR1C4 antibody) at dilution of 1:500
- Background
- Catalyzes the transformation of the potent androgen dihydrotestosterone(DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol(3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone(kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
