Products
AIRE antibody
- Product Name
- AIRE antibody
- Catalogue No.
- FNab00241
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- autoimmune regulator
- Alternative Names
- AIRE antibody, AIRE1 antibody, APECED antibody, APECED protein antibody, APS1 antibody, APSI antibody, autoimmune regulator antibody, PGA1 antibody
- UniProt ID
- O43918
- Observed MW
- 60 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-200
Validated Images
L02 cells were subjected to SDS PAGE followed by western blot with FNab00241(AIRE Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach slide using FNab00241(AIRE Antibody) at dilution of 1:50
- Background
- Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes(By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
