Products
AIM2 antibody
- Product Name
- AIM2 antibody
- Catalogue No.
- FNab00238
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- absent in melanoma 2
- Alternative Names
- Absent in melanoma 2 antibody, AIM2 antibody, PYHIN4 antibody
- UniProt ID
- O14862
- Observed MW
- 38-45 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-200
Validated Images
K-562 cells were subjected to SDS PAGE followed by western blot with FNab00238(AIM2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human testis using FNab00238(AIM2 antibody) at dilution of 1:100
- Background
- Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8(By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
