Products
Aggrecan antibody
- Product Name
- Aggrecan antibody
- Catalogue No.
- FNab00213
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- aggrecan
- Alternative Names
- ACAN antibody, AGC1 antibody, AGCAN antibody, aggrecan antibody, CSPG1 antibody, CSPGCP antibody, MSK16 antibody, SEDK antibody
- UniProt ID
- P16112
- Observed MW
- 70 kDa, 250-260 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:20-1:200
Validated Images
ROS1728 cells were subjected to SDS PAGE followed by western blot with FNab00213(ACAN Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human cartilage tissue slide using FNab00213(ACAN Antibody) at dilution of 1:100
- Background
- Aggrecan(ACAN), also named as CSPCP, AGC1 and MSK16, belongs to the aggrecan/versican proteoglycan family(also including versican, brevican and neurocan). It is a major component of extracellular matrix of cartilagenous tissues. A major function of aggrecan is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This polyclonal antibody raised against 1-298aa of human aggrecan reveals a band of 70 kDa, which is consistent with the molecular weight of degradation product generated by proteolysis at the aggrecanase site(PMID: 7852317; 9337874).
