Products
AGAP2 antibody
- Product Name
- AGAP2 antibody
- Catalogue No.
- FNab00205
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
- Alternative Names
- AGAP 2 antibody, AGAP2 antibody, Centaurin gamma 1 antibody, CENTG1 antibody, Cnt g1 antibody, FLJ16430 antibody, GGAP2 antibody, KIAA0167 antibody, PIKE antibody
- UniProt ID
- Q99490
- Observed MW
- 125 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
human brain tissue were subjected to SDS PAGE followed by western blot with FNab00205(AGAP2 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human gliomas using FNab00205(AGAP2 antibody) at dilution of 1:100
- Background
- GTPase-activating protein(GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1(GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1(AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
