Products
Adenylosuccinate lyase antibody
- Product Name
- Adenylosuccinate lyase antibody
- Catalogue No.
- FNab00161
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- adenylosuccinate lyase
- Alternative Names
- Adenylosuccinase antibody, adenylosuccinate lyase antibody, ADSL antibody, AMPS antibody, ASASE antibody, ASL antibody
- UniProt ID
- P30566
- Observed MW
- 55 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, FC
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab00161(ADSL antibody) at dilution of 1:400
Immunohistochemistry of paraffin-embedded human liver cancer using FNab00161(ADSL antibody) at dilution of 1:50
- Background
- ADSL(adenylosuccinate lyase) is also named as AMPS, ASase, ASL and belongs to the lyase 1 family. It is an enzyme involved in 2 pathways of purine nucleotide metabolism and catalyzes cleavage of succinyl groups to yield fumarate(PMID:18524658). Defects in ADSL are the cause of adenylosuccinase deficiency(ADSL deficiency). In humans, mutations in ADSL lead to an inborn error of metabolism originally characterized by developmental delay, often with autistic features(PMID:20884265)..The ADSL enzymatic activity is reduced in lymphocytes and red blood cells of the patient with severe psychomotor retardation(PMID:9545543). It has 2 isoforms produced by alternative splicing.
