Products
AATF antibody
- Product Name
- AATF antibody
- Catalogue No.
- FNab00025
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- apoptosis antagonizing transcription factor
- Alternative Names
- AATF antibody, CHE 1 antibody, CHE1 antibody, DED antibody, Protein AATF antibody, Rb binding protein Che 1 antibody, Traube antibody
- UniProt ID
- Q9NY61
- Observed MW
- 63 kDa
Application
- Tested Applications
- ELISA, WB, IF
- Recommended dilution
- WB: 1:200-1:2000; IF: 1:10-1:100
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00025(AATF antibody) at dilution of 1:800
- Background
- May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease(presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
