FineTest ELISA kit contributes to the research on intestinal permeability treatment. The immunoassay is designed to measure cytokine and endotoxin-related markers level in serum.
Article Title: Gut commensal Bacteroides-derived pantothenic acid alleviates metabolic syndrome
Journal Title: Cell Host & Microbe
DOI: 10.1016/j.chom.2026.06.005
IF: 23.2
PMID: 42385714
Abstract: Pantothenic acid (PA), or vitamin B5, can be synthesized by gut commensals, but the contribution of microbial PA to metabolic health remains unclear. Here, we find that microbial PA supply is reduced in individuals with metabolic syndrome (MetS) and is associated with impaired gut barrier function and disease severity. Tracing microbial PA identifies Bacteroides fragilis as a key contributor, with panC required for PA biosynthesis, as confirmed by isotope tracing, bacterial culture, and germ-free colonization. In MetS models, colonization with wild-type, but not ΔpanC B. fragilis, restores PA, preserves gut barrier integrity, reduces endotoxemia, and improves metabolic dysfunction. Mechanistically, microbial PA requires host pantothenate kinase activity, as silencing pantothenate kinase 2/3 (PANK2/3) in colonic organoids and in vivo reduces coenzyme A (CoA)/acetyl-CoA metabolism, suppresses Krüppel-like factor 4 (KLF4)-associated differentiation programs, and blunts the protective effects of microbial PA. Finally, a plant-derived polysaccharide enriches PA-producing Bacteroides and restores colonic PA, highlighting a strategy for colonic homeostasis and metabolic health.
Keywords: Intestinal permeability, Bacteroides fragilis, CoA, gut microbiota, intestinal barrier, metabolic syndrome, microbial metabolism, obetisy, pantothenate kinase, pantothenic acid, vitamin B5
Immunoassay
| FineTest Product | Sample | Species | Detection Target |
| Human LBP(Lipopolysaccharide-binding protein) ELISA Kit(EH1560) | serum | Human | LBP |
| Mouse LBP(Lipolysaccharide binding protein) ELISA Kit(EM1593) | Mouse | LBP | |
| Human HS-INS(High sensitive Insulin) Accquant ELISA Kit(EH0374) | Human | Insulin | |
| Mouse INS(Insulin) ELISA Kit(EM0260) | Mouse | Insulin | |
| Mouse TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit(EM0183) | Mouse | TNF-α | |
| Mouse IL-6(Interleukin 6) ELISA Kit(EM0121) | Mouse | IL-6 | |
| Mouse IL-1β(Interleukin 1 Beta) ELISA Kit(EM0109) | Mouse | IL-1β |
Validated Image
Figure Source: Cell Host Microbe. 2026 Jul 1:S1931-3128(26)00265-9. doi: 10.1016/j.chom.2026.06.005.