[Cited FineTest Antibody] Current Research on Innate Immunity and Cancer

FineTest antibody contributes to the research on innate immunity and cancer. Western blot is designed to measure γ-H2AX in MCF-7 cells.

Publication Details
Article Title: Ultra-efficient radio-immunotherapy for reprogramming the hypoxic and immunosuppressive tumor microenvironment with durable innate immune memory
Journal Title: Biomaterials
DOI: 10.1016/j.biomaterials.2023.122303
IF: 14
PMID: 37689049

Abstract:   Radiosensitization efficacy of conventional tumor radiosensitizers has been frequently limited by insufficient competence for tumor microenvironment (TME) regulation and unfavorable cellular uptake at biological barriers. Here, we reported an ultra-efficient radiotherapy (RT) strategy by synthesizing an extracellular vesicles (EVs)-encapsulated hollow MnO₂ to load metformin (Met@HMnER). It demonstrated significant RT enhancement by morphological control of catalyst and cellular respiratory depression against conventional solid MnO₂. Furthermore, the target-modified EVs clothing retains outstanding metformin loading capacity while endowing enhanced biological barrier penetration. A noticeably durable innate immune activation of NK cells was triggered with this nanoplatform via the cGAS-STING pathway. The enhanced immunocompetence was verified on distal metastasis and in-situ recurrence model in vivo, This work paved a new path for synergistic and robust innate immunity in clinical cancer treatment.

Keywords:    Hollow MnO₂, Innate immune effect, Radiotherapy, Tumor microenvironment, Ultra-high efficiency

Western Blot

Illustration

Figure Source: Biomaterials. 2023 Sep 5;302:122303. doi: 10.1016/j.biomaterials.2023.122303.