Products
VEGF antibody
- Product Name
- VEGF antibody
- Catalogue No.
- FNab09933
- Size
- 100μg
- Form
- liquid
- Purification
- protein A+G purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2b
- Clone ID
- 5H5
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- vascular endothelial growth factor A
- Alternative Names
- L VEGFA antibody, MVCD1 antibody, Vascular permeability factor antibody, VEGF antibody, VEGF A antibody, VEGFA antibody, VPF antibody
- UniProt ID
- P15692
- Observed MW
- 45 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:1000-1:4000; IHC: 1:50-1:500
Validated Images
MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab09933 (VEGF antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human stomach cancer tissue slide using FNab09933 (VEGF antibody) at dilution of 1:200
- Background
- VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1(MVCD1). VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189(38kd), VEFGA110(34kd). VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids(PMID:15602010). This antibody can recognize all the isoforms of VEFGA.
