[Cited FineTest ELISA Kit] Current Research on Immunogenic Cell Death

FineTest ELISA kit contributes to the research on immunogenic cell death. The immunoassay is designed to measure HMGB1 level in 4T1 cells.

Article Title: Tumor microenvironment–activated Zn//MnO2 battery for sustained and local electrochemical immunotherapy
Journal Title: Science Advances
DOI: 10.1126/sciadv.adu1647
IF: 11.7
PMID: 40435257

Abstract: Metal ions are widely adopted to potentiate oxidative damage-induced immunogenic cell death (ICD) and regulate immune pathways. However, current ion delivery platforms lack precise administration over distribution and retention time within the tumor microenvironment, leading to high systemic toxicity and suboptimal therapeutic efficacy. Here, local electrochemical immunotherapy is developed by implanting a tumor microenvironment–activated Zn//MnO2 battery, which uses body fluid as an electrolyte and endogenous glutathione as a redox mediator to promote sustained generation and localized retention of electrochemical products (Zn2+ and Mn2+). These elements trigger the ICD effect through reactive oxygen species accumulation and stimulate the STING pathway to activate immune cells effectively. Strategic placement of this battery around subcutaneous tumor sites results in a 99.6% growth inhibition rate after a 14-day treatment. This work demonstrates a powerful electrochemical tool for drug-free cancer immunotherapy, which may open an avenue for sustained and localized delivery of immune agonists.

Keywords: Immunogenic Cell Death, Immunotherapy, Immunology, Tumor Microenvironment, Drug Effects

Immunoassay

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Figure Source: Sci Adv. 2025 May 30;11(22):eadu1647. doi: 10.1126/sciadv.adu1647.