Products
Autotaxin antibody
- Product Name
- Autotaxin antibody
- Catalogue No.
- FNab10430
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ectonucleotide pyrophosphatase/phosphodiesterase 2
- Alternative Names
- ATX antibody, ATX X antibody, Autotaxin antibody, E NPP 2 antibody, ENPP2 antibody, FLJ26803 antibody, LysoPLD antibody, PD IALPHA antibody, PDNP2 antibody
- UniProt ID
- Q13822
- Observed MW
- 50kd, 60kd, 110-120kd
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:20-1:200
Validated Images
A549 cells were subjected to SDS PAGE followed by western blot with FNab10430(ENPP2 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab10430(ENPP2 Antibody) at dilution of 1:50
- Background
- Hydrolyzes lysophospholipids to produce lysophosphatidic acid(LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
