human heart tissue were subjected to SDS PAGE followed by western blot with FNab06886(PSMD14 antibody) at dilution of 1:400
Immunohistochemistry of paraffin-embedded human colon cancer using FNab06886(PSMD14 antibody) at dilution of 1:50
Background
Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks(DSBs): acts as a regulator of non-homologous end joining(NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.